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This work was supported by Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, PI13/01218, PI16/01209 and PI19/01356 to JM. Co-financed by European Development Regional Fund 'A way to achieve Europe'.

Analysis of institutional authors

Mingorance, JesusCorresponding Author

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November 13, 2024
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Dissemination of a single ST11 clone of OXA-48-producing Klebsiella pneumoniae within a large polyclonal hospital outbreak determined by genomic sequencing

Publicated to:Microbial Genomics. 8 (4): 000808- - 2022-04-01 8(4), DOI: 10.1099/mgen.0.000808

Authors: Lazaro-Perona, Fernando; Dahdouh, Elias; Sotillo, Alma; Perez-Blanco, Veronica; Villa, Jennifer; Viedma, Esther; Ruiz-Carrascoso, Guillermo; Mingorance, Jesus

Affiliations

Hosp Univ 12 Octubre, Serv Microbiol, Imas12, Ave Cordoba Sn, Madrid 28041, Spain - Author
Hosp Univ La Paz, Serv Med Prevent, IdiPAZ, Paseo Castellana 261, Madrid 28046, Spain - Author
Hosp Univ La Paz, Serv Microbiol, IdiPAZ, Paseo Castellana 261, Madrid 28046, Spain - Author

Abstract

The population structure of a set of OXA- 48-producing Klebsiella pneumoniae isolates belonging to sequence type 11 (ST11 KpOXA) and obtained from two hospitals in Madrid in the period from 2012 to 2015 was studied by genome sequencing. Overall, 97 ST11 Kp- OXA isolates were sequenced and their population structure and demography were studied by Bayesian phylodynamic analysis using core-genome SNVs. In total, 92 isolates were from Hospital La Paz, 57 of them from two selected units. The remaining five isolates were from different units of Hospital Doce de Octubre. Altogether, 96 out of the 97 ST11 Kp- OXA isolates could be ascribed to a single lineage that evolved into three sublineages. Demographic inference showed an expansion of the ST11 Kp- OXA in the first half of 2013 in agreement with the registered incidences. Dated phylogeny showed transmission clusters within hospital wards, between wards and between hospitals. The ST11 Kp- OXA outbreak in Hospital La Paz was largely due to the expansion of a single clone that was transmitted between different units and to Hospital Doce de Octubre. This clone diverged into three sub-lineages and spread out following a mixed mode of neutral core-genome evolution with some features of antibiotic selection, frequent large deletions and plasmid loss and gain events.

Keywords

Beta-lactamasesCarbapenemasesClone cellsEnterobacteriaceaeEpidemiologGenomic analysisHospital outbreakHospitalsHumansKlebsiella infectionsKlebsiella pneumoniaeKlebsiella-pneumoniaeOxa-48Oxa-48-producing klebsiella pneumoniaePhylodynamicPhylodynamicsSt11

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Microbial Genomics due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Microbiology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-03:

  • WoS: 3
  • Scopus: 4
  • Europe PMC: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (MINGORANCE CRUZ, JESUS).

the author responsible for correspondence tasks has been MINGORANCE CRUZ, JESUS.