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This study was funded by the Intercept Pharma collaboration, International Investigator Research Project 16034.

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Herranz Pinto, PedroAuthor

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Psoriasis and Liver Damage in HIV-Infected Patients

Publicated to:Cells. 10 (5): 1099- - 2021-05-01 10(5), DOI: 10.3390/cells10051099

Authors: Busca Arenzana, Carmen; Quintana Castanedo, Lucia; Chiloeches Fernandez, Clara; Nieto Rodriguez, Daniel; Herranz Pinto, Pedro; Delgado Hierro, Ana Belen; Olveira Martin, Antonio; Montes Ramirez, Maria Luisa

Affiliations

La Paz Univ Hosp, Dept Dermatol, Madrid 28046, Spain - Author
La Paz Univ Hosp, Dept Gastroenterol, Hepatol Unit, Madrid 28046, Spain - Author
La Paz Univ Hosp, HIV Unit, Dept Internal Med, Madrid 28046, Spain - Author

Abstract

Background/objectives: Psoriasis is the most frequent skin disease in HIV-infected patients. Nonalcohol fatty liver disease (NAFLD) is more prevalent in patients with psoriasis. We report the prevalence of psoriasis and NAFLD and investigate risk factors of liver damage in HIV-infected patients with psoriasis. Methods: We performed a retrospective observational study. Steatosis was defined as indicative abdominal ultrasound findings, CAP (controlled attenuated parameter by transient elastography) > 238 dB/m, and/or triglyceride and glucose index (TyG) > 8.38. Significant (fibrosis >= 2) and advanced liver fibrosis (fibrosis 10 and/or psoriatic arthritis) in 27.5% of cases. The prevalence of steatosis was 72.5% (95% CI, 65-85). Severe psoriasis was an independent risk factor for steatosis (OR, 12; 95% CI, 1.2-120; p = 0.03). Significant liver fibrosis (p < 0.05) was associated with HCV coinfection (OR 3.4; 95% CI, 1.1-10.6), total CD4 (OR 0.99; 95% CI, 0.99-1), and time of efavirenz exposure (OR 1.2; 95% CI, 1.0-1.3). Conclusions: The prevalence of psoriasis in HIV-infected patients was similar to that of the general population. Steatosis is highly prevalent, and severe psoriasis is an independent risk factor for steatosis in HIV-infected patients.

Keywords

AdultDiseaseEfavirenzElasticity imaging techniquesFatty liverFemaleFibrosisHivHiv infectionsHumansIncreasesLiverLiver cirrhosisLiver fibrosiLiver fibrosisMaleMiddle agedNafldPrevalencePsoriasisRisSteatosis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cells due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry, Genetics and Molecular Biology (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-22:

  • Google Scholar: 1
  • WoS: 1
  • Scopus: 2
  • Europe PMC: 1
  • OpenCitations: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 41.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 41 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.