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This research was funded by Ministerio de Ciencia, Innovacion y Universidades, Grant PID2021-125295OB-I00 funded by MICIU/AEI/10.13039/501100011033/FEDER, UE, the Junta de Extremadura and the European Regional Development Fund (ERDF/FEDER: "A way of making Europe"), through Grants No. GR21039 and TE-0060-19, as well as Grant PID2020-116692RB-I00 from the Ministerio de Ciencia y Educacion and co-funded by ERDF/FEDER. One of us (J.P.B.) is supported by an UCM-Santander predoctoral contract.

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Article

Antioxidant Activity and Hypoallergenicity of Egg Protein Matrices Containing Polyphenols from Citrus Waste

Publicated to:Antioxidants. 13 (10): 1154- - 2024-10-01 13(10), DOI: 10.3390/antiox13101154

Authors: Gil, Maria Victoria; Fernandez-Rivera, Nuria; Gutierrez-Diaz, Gloria; Parron-Ballesteros, Jorge; Pastor-Vargas, Carlos; Betancor, Diana; Nieto, Carlos; Cintas, Pedro

Affiliations

Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Dept Allergy & Immunol, Madrid 28049, Spain - Author
Univ Complutense Madrid, Fac Chem, Dept Biochem & Mol Biol, Madrid 28040, Spain - Author
Univ Extremadura, Fac Sci, Dept Organ & Inorgan Chem, IACYS Green Chem & Sustainable Dev Unit, Badajoz 06006, Spain - Author
Univ Salamanca, Fac Chem Sci, Dept Organ Chem, Pl Caidos S-N, Salamanca 37008, Spain - Author

Abstract

This study reports on the interactions of egg proteins, which represent a major health concern in food allergy, with polyphenols obtained from orange and lemon peels. The antioxidant properties of such citrus peel extracts prior to protein binding were evaluated. The resulting edible, and therefore inherently safe, matrices exhibit reduced IgE binding compared to pure proteins in indirect immunological assays (ELISA) using individual sera from patients allergic to ovalbumin and lysozyme. The reduced allergenicity could arise from the interactions with polyphenols, which alter the structure and functionality of the native proteins. It is hypothesized that the anti-inflammatory and antioxidant properties of the polyphenols, described as inhibitors of the allergic response, could add immunomodulatory features to the hypoallergenic complexes. A docking analysis using lysozyme was conducted to scrutinize the nature of the protein-polyphenol interactions. An in silico study unravelled the complexity of binding modes depending on the isoforms considered. Altogether, the presented results validate the antioxidant properties and reduced allergenicity of polyphenol-fortified proteins. Lastly, this study highlights the upgrading of vegetable wastes as a source of natural antioxidants, thus showing the benefits of a circular economy in agri-food science.

Keywords

AggregationAmyloid fibrillationAntioxidative actionBindingCircular economCircular economyDockingDocking simulationEgg proteinExtractioFood allergyImmunotherapyInhibitionLead finderMolecular-mechanicsOral immunotherapyPlant polyphenolsWhite lysozyme

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 50/313, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-30:

  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-30:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 38 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.