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CC received a grant from Spanish Society of Paediatric Rheumatology (SERPE), 2015. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Analysis of institutional authors

Villalobos Pinto, EnriqueAuthorCalvo, CristinaAuthorLopez Lopez, AgustinAuthorDeiros Bronte, LuciaAuthor

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Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development. (2011-2016): KAWA-RACE study group

Publicated to:PLoS ONE. 14 (5): e0215665- - 2019-05-20 14(5), DOI: 10.1371/journal.pone.0215665

Authors: Fernandez-Cooke, Elisa; Barrios Tascon, Ana; Sanchez-Manubens, Judith; Anton, Jordi; Grasa Lozano, Carlos Daniel; Aracil Santos, Javier; Villalobos Pinto, Enrique; Clemente Garulo, Daniel; Mercader Rodriguez, Beatriz; Bustillo Alonso, Matilde; Nunez Cuadros, Esmeralda; Navarro Gomez, Maria Luisa; Dominguez-Rodriguez, Sara; Calvo, Cristina; Moreno Perez, David; Martin Cantero, Maria; Carazo Gallego, Begona; Martinez Campos, Leticia Isabel; Sanchez Garcia, Fernando; Camacho Lovillo, Marisol; Marques, Renata; Neth, Olaf; Fernandez Silveira, Laura; Sanchez Forte, Miguel; Ortega Montes, Angeles; Bravo Mancheno, Beatriz; Camacho, Margarita; Medina Claros, Antonio F; Salido, Carlos; Chulian Cruz, Rafael; Torres Rico, Maria; Tejero Hernandez, Ma Angeles; Gomez Guzman, Elena; Arroyo Marin, Ma Jose; Rumbao Aguirre, Jose; Lirola Cruz, Ma Jose; Maya Carrasco, Kety; Rodriguez Gonzalez, Moises; Blanca Jover, Enrique; Ruiz Lopez, Aida; Uberos Fernandez, Jose; Ibanez Alcalde, Maria Mercedes; Collado, Pilar; Guerrero Laleona, Carmelo; Jimenez Montanes, Lorenzo; Ayerza Casas, Ariadna; Montes Zapico, Barbara; Perez Mendez, Carlos; Fernandez Aracama, Javier; Rodriguez, Lucia; Ibanez Fernandez, Maria Aleida; Navarro Campo, Sandra; Escriba Bori, Silvia; Mir Perello, Maria Concepcion; de la Fuente Sanchez, Ma Angeles; Aparicio Garcia, Patricia; Briales, Carlos; Castilla Crespi, Joaquin; Colino Gil, Maria Elena; Delgado Cabrera, Nerea; Bello Naranjo, Ana; Poch Paez, Jesus; Garcia Yanez, Moneyba; Gonzalez Garcia, Montse; Pereira Bezanilla, Elena; Jimenez Montero, Beatriz; Dominguez Garcia, Olga; Losada Pinedo, Begona; Inigo Martin, Gema; Escribano Gomez, Lucia Maria; Cepillo, Antonio; Lillo Lillo, Miguel; Isabel Buedo, Maria; del Rey, Laura; Urbaneja Rodriguez, Elena; Rellan Rodriguez, Sara; Cantero, Teresa; Plata Izquierdo, Beatriz; Garcia-Cuenllas Alvarez, Luisa; Oulego Erroz, Ignacio; Perez Santaolalla, Elena; Alcalde Martin, Carlos; Centeno Malfaz, Fernando; Perez Gutierrez, Elena; Jimenez Casso, Marisol; Prada, Fredy; Bou, Rosa; Iglesias, Estibaliz; Calzada, Joan; Calavia Garsaball, Olga; Tobena Rue, Marc; Giralt Garcia, Gemma; Yevenes Ruiz, Silvia; Lobato, Zulema; Rius Gordillo, Neus; Pascual Torres, Montserrat; Mendez Hernandez, Maria; Garcia, Lourdes; Flores Villar, Sergio; Minguell Domingo, Laura; Ballester, Anna; Miralles, Ana; Pujol Soler, Berta; Foguet Vidal, Anton; Sala Castellvi, Pere; Serrano Aguiar, Angelita; Siurana Rodriguez, Jose Manuel; Sangorrin Iranzo, Anna; Alvarez Perez, Roser; Ribes Cajas, Paula; Genaro i Jornet, Pere; Grande Tejada, Ana; Zarallo, Cristina; Martinon-Torres, Federico; Rivero Calle, Irene; Justicia Grande, Antonio; Ruiz Saez, Beatriz; Lopez Sousa, Maria; Souto Vilas, Alejandro; Lopez Abe, Bernardo; de Miguel Esteban, Elisa; Riano Mendez, Bibiana; Blazquez, Daniel; Rojo Conejo, Pablo; Gonzalez Tome, Maribel; Grasa Lozano, Carlos; Toral, Belen; Albert De la Torre, Leticia; de Inocencio, Jaime; Santos, Mar; Diaz-Delgado de la Pena, Rafael; Collado Ramos, Paz; Tagarro, Alfredo; Raga, Teresa; Latorre, Libertad; Guillen, Sara; Callejas Caballero, Ignacio; Prieto Tato, Luis Manuel; Guzman Monagas, Maria Fernanda; Jimenez Lopez, Isabel; Villagra, Sandra; Arreo, Viviana; Pineiro Perez, Roi; de la Parte, Maria; Tamariz-Martes, Amalia; Llorente Romano, Marta; Hernandez Ruperez, Belen; Rodriguez Martin, Sonia; Rojo Sombrero, Henar; Garcia Cerro, Estefania; Mate Cano, Irene; Villares Alonso, Marta; Osuna Marco, Marta Pilar; Jensen Veron, Julia; Rodriguez Mesa, Maria Dolores; Rueda Esteban, Santiago; Ramos Amador, Jose Tomas; Gonzalez Menchen, Cristina; Jimenez Jimenez, Ana Belen; Galan, Pilar; Perez Campos, Dolores; Mercedes Bueno, Ma; Crespo Marcos, David; de Tejada Barasoain, Enrique Otheo; Sifuentes Giraldo, Walter Alberto; Gamir Gamir, Maria Luz; Cilleruelo Ortega, Maria Jose; Lopez Lopez, Agustin; Sanchez Vaquerizo, Cristina; Usano Carrasco, Ana Isabel; Moreno Gomez, Ester; Carrasco Colom, Jaime; Carvajal del Castillo, Olga; Del Pozo Menendez, Beatriz; Badillo Navarro, Katie; Baquero, Fernando; Deiros Bronte, Lucia; Fernandez Fraga, Pablo; Dominguez, Nieves; Castro Garcia, Francisco; Vera Romero, Elena; Herrera Chamorro, Agueda; Alcaniz Rodriguez, Paula; Sorli Garcia, Moises; Rex Nicolas, Maria Concepcion; Lorente Nicolas, Ana; Martinez Oloron, Patricia; Rocandio Cilveti, Beatriz; Berridi, Amaia; Santos-Diez Vazquez, Laura; Fernandez, Olaia; Perez Tamarit, Amparo; Calvo, Inmaculada; Lopez, Berta; Gonzalez Fernandez, Ma Isabel; Carmen Otero, Ma; Oltra, Manuel; Dapena Archiles, Marta; Sanchez, Paco; Gavilan, Cesar; Izquierdo Fos, Ignacio; Serrano Robles, Maria Isabel; Herranz Sanchez, Yolanda

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Abstract

Background Kawasaki disease (KD) is an acute self-limited systemic vasculitis of unknown etiology affecting mainly children less than 5 years of age. Risk factors for cardiac involvement and resistance to treatment are insufficiently studied in non-Japanese children. Objective This study aimed to investigate the epidemiology, clinical features and risk factors for resistance to treatment and coronary artery lesions (CAL) in KD in Spain. Methods Retrospective study (May 2011-June 2016) of all patients less than 16 years of age diagnosed with KD included in KAWA-RACE network (84 Spanish hospitals). Results A total of 625 cases were analyzed, 63% were males, 79% under 5 year-olds and 16.8% younger than 12 months. On echocardiographic examination CAL were the most frequent findings (23%) being ectasia the most common (12%). Coronary aneurysms were diagnosed in 9.6%, reaching 20% in infants under 12 months (p 900,000 cells/mm(3), maximum temperature < 39.5 degrees C, total duration of fever > 10 days and fever before treatment >= 8 days as independent risk factors for developing coronary aneurysms. Conclusions In our population, children under 12 months develop coronary aneurysms more frequently and children with KD with anemia and leukocytosis have high risk of cardiac involvement. Adding steroids early should be considered in those patients, especially if the treatment is not started before 8 days of fever. A score applicable to non-Japanese children able to predict the risk of aneurysm development and IVIG resistance is necessary.

Keywords

AssociationCoronary-artery abnormalitiesHealth-professionalsIntravenous gamma-globulinLong-term managementPredictionResistanceStatemenSurveillanceSusceptibility

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLoS ONE due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.26. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 13.67 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-27, the following number of citations:

  • WoS: 51
  • Scopus: 50
  • Google Scholar: 67
  • OpenCitations: 41

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 81.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 81 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 107.55.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 136 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.