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Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

Publicated to:NEUROLOGY. 63 (12): 2348-2353 - 2004-12-28 63(12), DOI: 10.1212/01.wnl.0000147478.03911.28

Authors: Olazarán, J; Muñiz, R; Reisberg, B; Peña-Casanova, J; del Ser, T; Cruz-Jentoft, AJ; Serrano, P; Navarro, E; de la Rocha, MLG; Frank, A; Galiano, M; Fernández-Bullido, Y; Serra, JA; González-Salvador, MT; Sevilla, C

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Abstract

Objective: To evaluate the efficacy of a cognitive-motor program in patients with early Alzheimer disease ( AD) who are treated with a cholinesterase inhibitor (ChEI). Methods: Patients with mild cognitive impairment (MCI) (12), mild AD ( 48), and moderate AD ( 24) ( Global Deterioration Scale stages 3, 4, and 5) were randomized to receive psychosocial support plus cognitive-motor intervention ( experimental group) or psychosocial support alone ( control group). Cognitive-motor intervention (CMI) consisted of a 1-year structured program of 103 sessions of cognitive exercises, plus social and psychomotor activities. The primary efficacy measure was the cognitive subscale of the AD Assessment Scale (ADAS-cog). Secondary efficacy measures were the Mini-Mental State Examination, the Functional Activities Questionnaire, and the Geriatric Depression Scale. Evaluations were conducted at 1, 3, 6, and 12 months by blinded evaluators. Results: Patients in the CMI group maintained cognitive status at month 6, whereas patients in the control group had significantly declined at that time. Cognitive response was higher in the patients with fewer years of formal education. In addition, more patients in the experimental group maintained or improved their affective status at month 12 (experimental group, 75%; control group, 47%; p = 0.017). Conclusions: A long-term CMI in ChEI-treated early Alzheimer disease patients produced additional mood and cognitive benefits.

Keywords

Cholinesterase-inhibitorsControlled-trialsDementiaMemorMini-mental stateReality orientationScale

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NEUROLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2004, it was in position 5/139, thus managing to position itself as a Q1 (Primer Cuartil), in the category Clinical Neurology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 36.33, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-01, the following number of citations:

  • WoS: 199
  • Scopus: 239
  • OpenCitations: 253

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 350.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 348 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.