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Burden of diabetes and hyperglycaemia in adults in the Americas, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Publicated to:Lancet Diabetes & Endocrinology. 10 (9): 655-667 - 2022-08-23 10(9), DOI: 10.1016/S2213-8587(22)00186-3

Authors: Cousin, Ewerton; Schmidt, Maria Ines; Ong, Kanyin Liane; Lozano, Rafael; Afshin, Ashkan; Abushouk, Abdelrahman I; Agarwal, Gina; Agudelo-Botero, Marcela; Al-Aly, Ziyad; Alcalde-Rabanal, Jacqueline Elizabeth; Alvis-Guzman, Nelson; Alvis-Zakzuk, Nelson J; Antony, Benny; Asaad, Malke; Baernighausen, Till Winfried; Basu, Sanjay; Bensenor, Isabela M; Butt, Zahid A; Campos-Nonato, Ismael R; Chattu, Vijay Kumar; Criqui, Michael H; Daneshpajouhnejad, Parnaz; Davila-Cervantes, Claudio Alberto; Denova-Gutierrez, Edgar; Dharmaratne, Samath Dhamminda; Diaz, Daniel; Filip, Irina; Gad, Mohamed M; Garcia-Gordillo, M A; Assl, Shakiba Ghasemi; Gopalani, Sameer Vali; Guimaraes, Rafael Alves; Gupta, Rajat Das; Hafezi-Nejad, Nima; Hashemian, Maryam; Hay, Simon I; Kahlon, Tanvir; Khubchandani, Jagdish; Kimokoti, Ruth W; Kisa, Adnan; Defo, Barthelemy Kuate; Landires, Ivan; Miller, Ted R; Mokdad, Ali H; Morales, Linda; Morrison, Shane Douglas; Nigatu, Yeshambel T; Nunez-Samudio, Virginia; Olagunju, Andrew T; Pandi-Perumal, Seithikurippu R; Patel, Urvish K; Radfar, Amir; Rios-Blancas, Maria; Roever, Leonardo; Saadatagah, Seyedmohammad; Sanabria, Juan; Santos, Itamar S; Sathish, Thirunavukkarasu; Shabani, Mahsima; Shafaat, Omid; SantosSilva, Diego Augusto; Singh, Ambrish; Singh, Jasvinder A; Tovani-Palone, Marcos Roberto; Velazquez, Diana Zuleika; Zadey, Siddhesh; Naghavi, Mohsen; Vos, Theo; Duncan, Bruce B

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Abstract

Background High prevalence of diabetes has been reported in the Americas, but no comprehensive analysis of diabetes burden and related factors for the region is available. We aimed to describe the burden of type 1 and type 2 diabetes and that of hyperglycaemia in the Americas from 1990 to 2019. Methods We used estimates from GBD 2019 to evaluate the burden of diabetes in adults aged 20 years or older and high fasting plasma glucose in adults aged 25 years or older in the 39 countries and territories of the six regions in the Americas from 1990 to 2019. The main source to estimate the mortality attributable to diabetes and to chronic kidney disease due to diabetes was vital registration. Mortality due to overall diabetes (ie, diabetes and diabetes due to chronic kidney disease) was estimated using the Cause of Death Ensemble model. Years of life lost (YLLs) were calculated as the number of deaths multiplied by standard life expectancy at the age that the death occurred, years lived with disability (YLDs) were estimated based on the prevalence and severity of complications of diabetes. Disability-adjusted life-years (DALYs) were estimated as a sum of YLDs and YLLs. We assessed the association of diabetes burden with the level of development of a country (according to the Socio-demographic Index), health-care access and quality (estimated with the Healthcare Access and Quality Index), and diabetes prevalence. We also calculated the population attributable fraction (PAF) of diabetes burden due to each of its risk factors. We report the 95% uncertainty intervals for all estimates. Findings In 2019, an estimated total of 409-000 (95% uncertainty interval 373-000443-000) adults aged 20 years or older in the Americas died from diabetes, which represented 5.9% of all deaths. Diabetes was responsible for 2266 (19302649) crude DALYs per 100-000 adults in the Americas, and high fasting plasma glucose for 4401 DALYs (36855265) per 100-000 adults, with large variation across regions. DALYs were mostly due to type 2 diabetes and distribution was heterogeneous, being highest in central Latin America and the Caribbean and lowest in high-income North America and southern Latin America. Between 1990 and 2019, age-standardised DALYs due to type 2 diabetes increased 27.4% (22.032.5). This increase was particularly high in Andean Latin America and high-income North America. Burden for both type 1 and type 2 diabetes across countries increased with higher diabetes prevalence and decreased with greater Socio-demographic and Healthcare Access and Quality Indices. Main risk factors for the burden were high BMI, with a PAF of 63.2% and dietary risks, with a PAF of 27.5%. The fraction of burden due to disability has increased since 1990 and now represents nearly half of the overall burden in 2019. Interpretation The burden of diabetes in the Americas is large, increasing, heterogeneous, and expanding. To confront the rising burden, population-based interventions aimed to reduce type 2 diabetes risk and strengthening health systems to provide effective and cost-efficient care for those affected are mandatory. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.

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