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Grant support

Financial support was provided by the Spanish Government (PID2021-122299NB-I00, TED2021-130470B-I00, and TED2021-129999B-C32), European Structural Funds (S2018/NMT-4367), Proyectos Sinergicos I + D (Y2020/NMT6469) and 'Comunidad de Madrid' (SI1/PJI/2019-00237). M. J. G. thanks the Spanish Government for a FPI contract (PRE2019-090203) and L. M. thanks the Spanish Government for a Ramon y Cajal contract (RYC2021-031590-I).

Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

García M.j.AuthorGarcia, Montana JAuthorCabrera, SilviaCorresponding AuthorMarzo, LeyreCorresponding AuthorAleman, JoseCorresponding Author

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October 1, 2024
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Electrochemically driven green synthesis to unlock sustainable routes to β-keto spirolactones

Publicated to:GREEN CHEMISTRY. 26 (11): 6553-6558 - 2024-04-18 26(11), DOI: 10.1039/d4gc01127a

Authors: Maclean, Ian; Garcia, Montana J; Cabrera, Silvia; Marzo, Leyre; Aleman, Jose

Affiliations

Organ Chem Dept Modulo 1 Univ Autonoma Madrid, Organ Chem Dept Modulo 1, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Inorgan Chem Dept Modulo 7, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain - Author

Abstract

In this work, we present a sustainable and environmentally benign electrochemical method for the synthesis of beta-keto spirolactones. The reaction is carried out using green solvents such as acetone and water, and simple electrons as oxidants, instead of the stoichiometric oxidants used in classical approaches. The robustness of the method allows the functionalization of cyclic beta-keto esters and a beta-keto amide, the latter affording alpha-spiroiminolactone. The method also gives good results with double bonds bearing substituents of different electronic natures. Furthermore, this methodology can be easily scalable through a continuous flow electrochemical approach that improves the productivity of the reaction. Mechanistic investigations support the radicalic nature of the transformation, and the generation of a carbocation intermediate that is further trapped with the water employed as co-solvent in the reaction. A sustainable method efficiently synthesizes beta-keto spirolactones using green solvents under electrochemical conditions.

Keywords

Responsible consumption and production

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal GREEN CHEMISTRY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 14/91, thus managing to position itself as a Q1 (Primer Cuartil), in the category Green & Sustainable Science & Technology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-06:

  • WoS: 1
  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 1.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 1 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 5.8.
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/713737
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 12 - Ensure sustainable consumption and production patterns, with a probability of 45% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MacLean, Ian) and Last Author (ALEMAN LARA, JOSE JULIAN).

the authors responsible for correspondence tasks have been CABRERA HERRANZ, SILVIA, MARZO PUERTA, LEYRE and ALEMAN LARA, JOSE JULIAN.