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Grant support

This article was supported by the National Alliance for Research of Schizophrenia and Affective Disorders (NARSAD), and by the Spanish Health Ministry (Instituto de Salud Carlos III, CIBERSAM). Dr Vaquero-Lorenzo is the recipient of a grant of the Spanish Ministry of Economy and Competitiveness (Juan de la CiervaProgramme JCI-2011-11050). Dr Baca-Garcia is the Lilly Suicide Scholar at Columbia University. The authors thank Rosa Nunes for editorial assistance.

Analysis of institutional authors

Vaquero Lorenzo, ConcepcionAuthorFernandez Piqueras, JoseAuthorBaca Garcia, EnriqueAuthor

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September 19, 2024
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Putative association between the-1415 T/C polymorphism of spermidine/spermine N1-acetyltransferase (SSAT1) gene and alcohol use disorders in women and men

Publicated to:AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE. 40 (3): 240-243 - 2014-05-01 40(3), DOI: 10.3109/00952990.2014.891039

Authors: Vaquero-Lorenzo, Concepcion; Lopez-Castroman, Jorge; Riaza Bermudo-Soriano, Carlos; Saiz-Ruiz, Jeronimo; Fernandez-Piqueras, Jose; Baca-Garcia, Enrique

Affiliations

CHRU Montpellier, Dept Emergency Psychiat, F-34000 Montpellier, France - Author
CIBERSAM, IRYCIS, Univ Hosp Ramon & Cajal, Dept Psychiat, Madrid, Spain - Author
ISCIII, CIBERER, Madrid, Spain - Author
New York State Psychiat Inst & Hosp, Dept Psychiat, New York, NY 10032 USA - Author
Univ Autonoma Madrid, CSIC, CBMSO, Madrid, Spain - Author
Univ Autonoma Madrid, Fdn Jimenez Diaz, IIS, Dept Psychiat,CIBERSAM, Madrid, Spain - Author
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Abstract

Background: The activity of N-methyl-D-aspartate (NMDA) glutamate receptor, which responds to the levels of polyamines, modifies the neurotoxicity caused by ethanol. We aimed to investigate if the functionality of the spermidine/ spermine N1-acetyltransferase (SSAT1) gene could be associated with a differential risk for alcoholism. Methods: We studied a sample of 586 subjects: 104 alcohol-dependent patients, 273 patients with psychiatric disorders but without substance dependence, and 209 healthy controls. After gender stratification, the allele frequency distribution of the SSAT1 gene was compared between these three groups. Results: In females, the TC genotype was significantly more frequent in alcohol-dependent patients than in non-alcohol-dependent psychiatric controls (chi(2) = 7.509 df = 2, p = 0.023). A trend was found when alcohol-dependent females were compared with the healthy control group (chi(2) = 4.897 df = 2, p = 0.086). No statistical differences were found among the males. Discussion and conclusion: Gender differences in the regulation of SSAT1 gene expression may possibly be due to gender-specific effects of stress, ethanol toxicity, and/or polyamines levels. Further studies are needed to confirm our findings.

Keywords

DependenceEthanolPolyamines

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-26:

  • WoS: 3
  • Scopus: 2
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-26:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (VAQUERO LORENZO, CONCEPCION) and Last Author (BACA GARCIA, ENRIQUE).