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3 760,00 Dollars

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25

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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Abad-Santos F.AuthorCarcas A.j.AuthorGuerra P.AuthorFrias J.Author

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September 13, 2024
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Article
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Evaluation of sex differences in the pharmacokinetics of ranitidine in humans

Publicated to: JOURNAL OF CLINICAL PHARMACOLOGY. 36 (8): 748-751 - 1996-08-01 36(8), DOI: 10.1002/j.1552-4604.1996.tb04245.x

Authors:

AbadSantos, F; Carcas, AJ; Guerra, P; Govantes, C; Montuenga, C; Gomez, E; Fernandez, A; Frias, J
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Affiliations

- Author
Hospital Universitario La Paz - Author
Hospital Universitario La Paz; Hospital Universitario La Paz - Author
Normon SA Laboratories - Author
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Abstract

A bioequivalence study of two oral formulations of 300 mg ranitidine was carried out in 16 healthy volunteers (8 men and 8 women), and the pharmacokinetics in both sexes were compared. There was bioequivalence of both formulations. The terminal half-life of ranitidine was 7% shorter and the oral apparent clearance 10.5% higher in women (1.44 L/h/kg) than in men (1.29 L/h/kg), although this difference did not reach statistical significance. No differences were observed in maximum concentration (C(max)) or the time of its occurrence (t(max)). Sex, age, and weight did not correlate significantly with oral clearance. These results suggest that there are sex differences in the pharmacokinetics of ranitidine, or that any differences would not be of clinical relevance. It also should be emphasized that bioequivalence trials also can be used to study other pharmacokinetics or pharmacodynamic characteristics of drugs without damaging the main endpoint of the study.
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Keywords

Good health and well-being

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • Open Alex: 11
  • WoS: 8
  • Scopus: 13
  • Europe PMC: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 78% according to the mBERT algorithm developed by Aurora University.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (ABAD SANTOS, FRANCISCO) and Last Author (FRIAS INIESTA, JESUS A.).

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