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Grant support

We thank the European Research Council (ERC Consolidator Grant - 101002715 - SCAN) and the Spanish Ministry of Science and Innovation (MICINN) [PID2022-142594NB-I00] for financial support. M. M. and C. P.-S. acknowledge Ministerio de Universidades and MICINN for FPU (FPU20/06320) and for FPI (PREP2022-000243) fellowships, respectively.

Analysis of institutional authors

Martin Martin, MariaAuthorMartin MAuthorMartin, MariaAuthorPerez-Sanchez, CarlaAuthorRigotti, ThomasAuthorTortosa, MariolaCorresponding Author

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September 8, 2024
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Article

Trityl isocyanide as a general reagent for visible light mediated photoredox-catalyzed cyanations

Publicated to:Chemical Science. 15 (35): 14188-14194 - 2024-08-06 15(35), DOI: 10.1039/d4sc04199b

Authors: Quiros, Irene; Martin, Maria; Perez-Sanchez, Carla; Rigotti, Thomas; Tortosa, Mariola

Affiliations

Autonomous Univ Madrid UAM, Fac Sci, Organ Chem Dept, Madrid 28049, Spain - Author
Autonomous Univ Madrid UAM, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain - Author
Univ Autonoma Madrid UAM, Ctr Innovat Adv Chem ORFEO CINQA, Madrid 28049, Spain - Author

Abstract

A photoredox catalytic strategy has been developed to enable the functionalization of a variety of commercially available, structurally different radical precursors by the use of a bench-stable isonitrile as an efficient cyanating reagent. Specifically, a radical-based reaction has provided a mild and convenient procedure for the cyanation of primary, secondary and tertiary radicals derived from widely accessible sp3-hybridized carboxylic acids, alcohols and halides under visible light irradiation. The reaction tolerates a variety of functional groups and it represents a complementary method for the cyanation of structurally different scaffolds that show diverse native functionalities, expanding the scope of previously reported methodologies. Bench-stable trityl isocyanide enables the photoredox catalytic cyanation of carboxylic acids, alcohols and alkyl halides.

Keywords

AcidNitrileRadicalsTertiary alkyl chlorides

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Chemical Science due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 40/231, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-06:

  • WoS: 1
  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.05.
  • The number of mentions on the social network X (formerly Twitter): 21 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/715517

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Quiros, Irene) and Last Author (Tortosa Manzanares, Mariola).

the author responsible for correspondence tasks has been Tortosa Manzanares, Mariola.