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Analysis of institutional authors

Gago-Veiga, Ana BeatrizAuthor

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August 4, 2024
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The profile of refractory chronic cluster headache

Publicated to: Neurological Sciences. 46 (1): 295-302 - 2025-01-01 46(1), DOI: 10.1007/s10072-024-07708-0

Authors:

Membrilla, Javier A; Membrilla, Javier A; Cuadrado, Maria-Luz; Gonzalez-Garcia, Nuria; Porta-Etessam, Jesus; Sanchez-Soblechero, Antonio; Ros, Alberto Lozano; Gonzalez-Martinez, Alicia; Gago-Veiga, Ana Beatriz; Quintas, Sonia; Vico, Jaime S Rodriguez; Vico, Jaime S Rodriguez; Jaimes, Alex; Ayuso, Lucia Llorente; Roa, Javier; Estebas, Carlos; Diaz-de-Teran, Javier
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Affiliations

Hosp Clin San Carlos, Dept Neurol, Madrid, Spain - Author
Hosp Univ Fdn Jimenez Diaz, Neurol Dept, Madrid, Spain - Author
Hosp Univ Francesc de Borja, Dept Neurol, Avinguda Med 6, Valencia 46702, Spain - Author
Hosp Univ Gregorio Maranon, Dept Neurol, Madrid, Spain - Author
Hosp Univ Infanta Leonor, Pediat Dept, Madrid, Spain - Author
Hosp Univ La Paz, Neurol Dept, Madrid, Spain - Author
Hosp Univ La Princesa, Neurol Dept, Madrid, Spain - Author
Univ Autonoma Madrid, Hosp La Paz Inst Hlth Res IdiPAZ, Getafe Univ Hosp, La Paz Univ Hosp,Univ Europea Madrid, Madrid, Spain - Author
Univ Complutense, Dept Med, Madrid, Spain - Author
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Abstract

IntroductionChronic cluster headache (CCH) is a relatively rare primary headache disorder whose management is often challenging. The prevalence of refractory CCH (rCCH) is unknown. Our aim is to describe the frequency of rCCH within a population of CCH, define the clinical profile of the refractory patients and the treatments they underwent.MethodsWe conducted a cross-sectional study through a review of the medical records of CCH patients in six hospitals in Madrid, Spain. Data on epidemiological, clinical presentation, treatment and disease activity at the moment were collected. The European Headache Federation diagnostic criteria were used for rCCH definition. High disease activity was defined as having at least 3 severe attacks per week that impact quality of life despite treatment. Non-rCCH and rCCH groups were compared.Results88 CCH patients were analyzed, 68.2% (60/88) met rCCH criteria at some point in their evolution. A longer diagnostic delay (4.6 +/- 7.1 vs. 3.2 +/- 3.7 years, p = 0.017) was observed in rCCH. All rCCH patients tried therapies without established evidence from randomized clinical trials. OnabotulinumtoxinA and galcanezumab were initiated in 77.3% (68/88) and 5.7% (5/88), but discontinued in 52.9% (36/68) and 60.0% (3/5), respectively. Occipital nerve stimulation (ONS) was implanted in 29.6% (26/88), with 50.0% (13/26) still active. Other treatment options are described and discussed. Despite treatment, 60.2% (53/88) still have high disease activity.ConclusionCCH is a disorder with poor prognosis, meeting refractoriness criteria in more than half. OnabotulinumtoxinA and ONS could be the effective in refractory patients.
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Keywords

CgrpChronicCluster headacheGalcanezumaGalcanezumabNeuromodulationOccipital nerve stimulationRefractoryTreatment

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal NEUROLOGICAL SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Dermatology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-04:

  • WoS: 4
  • Scopus: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Diaz-de-Teran, Javier).

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Awards linked to the item

DAS:Datasets are available upon contacting the corresponding author.
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