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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Gandía L.AuthorGarcía A.g.Corresponding Author

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July 27, 2024
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The amyotrophic lateral sclerosis SOD1G93A mouse model and applications: Studies into the P2X7 receptor

Publicated to:Handbook Of Animal Models In Neurological Disorders. 81-94 - 2022-01-01 (), DOI: 10.1016/B978-0-323-89833-1.00048-3

Authors: Puig C; Fernández A; Gandía L; García AG

Affiliations

Universidad Autónoma de Madrid - Author

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressively incapacitating, adult onset neurodegenerative disease. It is essentially a motor neuron disease with progressive paralysis and death 3–5years after diagnosis. The only available medications are riluzole and edaravone, but they do not affect disease progression. Several gene mutations found in ALS patients have been modeled in mice; the mutations of superoxide dismutase 1 (SOD1) were first identified and modeled in mice. The SOD1G93A mouse model best reproduced the ALS hallmarks, and hence, it has been the most widely used model to establish the proof of concept of new drugs with potential therapeutic actions in ALS. Several drug targets have been identified in drug development programs. Recently, increasing interest has been manifested for the purinergic receptor P2X7 (P2X7R) that is tightly implicated in neuroinflammation, a relevant pathway in disease pathogenesis. We describe in detail the generation of the SOD1G93A mice colony, the protocol for chronic drug and placebo administration to these mice, the experimental groups, the phenotypic variables being tested along the period of drug treatment to observe disease progression, and the tissue biomarkers evaluated at the end of the experimental protocol. Six reports using three different P2X7R blockers have been published so far. We comment on the protocol and the outcomes that have been quite variable. We next analyze the possible causes for this variability and suggest new protocols to establish the proof of concept of new compounds in the SOD1G93A mouse model of ALS.

Keywords

Good health and well-being

Quality index

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 1 (PlumX).
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 86% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Puig C.) and Last Author (GARCIA GARCIA, ANTONIO).

the author responsible for correspondence tasks has been GARCIA GARCIA, ANTONIO.