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This research received no external funding. P.C. was supported by a grant, "Severo Ochoa Program", from the Government of the Principality of Asturias (PA-21-PF-BP20-122).

Analysis of institutional authors

Garcia-Piqueras, JorgeAuthor

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July 10, 2024
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Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25 (12): 6722- - 2024-06-01 25(12), DOI: 10.3390/ijms25126722

Authors: Cuendias, Patricia; Vega, Jose A; Garcia-Suarez, Olivia; Suazo, Ivan; Cobo, Ramon; Garcia-Piqueras, Jorge; Garcia-Mesa, Yolanda

Affiliations

Hosp Univ Marques Valdecilla, Serv Otorrinolaringol, Santander 39008, Spain - Author
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain - Author
Univ Autonoma Chile, Fac Ciencias Salud, Santiago 4810010, Providencia, Chile - Author
Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Madrid 28049, Spain - Author
Univ Oviedo, Dept Morfol & Biol Celular, Grp Invest SINPOS, Oviedo 33006, Spain - Author
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Abstract

Krause's corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part of the cationic ion channels required for mechanosensitivity in mammalian cells. They are involved in somatosensitivity, especially in the different qualities of touch, but also in pain and proprioception. In the present study, immunohistochemistry and immunofluorescence were used to analyze the occurrence and cellular location of PIEZO1 and PIEZO2 in human clitoral Krause's corpuscles. Both PIEZO1 and PIEZO2 were detected in Krause's corpuscles in both the axon and the terminal glial cells. The presence of PIEZOs in the terminal glial cells of Kraus's corpuscles is reported here for the first time. Based on the distribution of PIEZO1 and PIEZO2, it may be assumed they could be involved in mechanical stimuli, sexual behavior, and sexual pleasure.

Keywords

AdultAnatomyAxonsCellClitorisFemaleHumaHumanHumansImmunohistochemistryIon channelsKrause's corpusclesKrause’s corpusclesMechanoreceptorsMiddle agedNeurogliaPiezo mechanoproteinsPiezo1 protein, humanPiezo2 protein, humanReceptorsSensory neuronsTerminal glial cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 68/231, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 1.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 1 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile.