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Analysis of institutional authors

Méndez-Echevarría AAuthorSainz TAuthor
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Article

QuantiFERON-TB reversion in children and adolescents with tuberculosis.

Publicated to:Frontiers in Immunology. 15 1310472- - 2024-01-01 15(), DOI: 10.3389/fimmu.2024.1310472

Authors: Rodríguez-Molino P; González Sánchez A; Noguera-Julián A; Soler-García A; Martínez Paz P; Méndez-Echevarría A; Baquero-Artigao F; González Muñoz M; Ruíz-Serrano MJ; Monsonís M; Sánchez León R; Saavedra-Lozano J; Santiago-García B; Sainz T

Affiliations

Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain. - Author
Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. - Author
Department of Immunology, Hospital La Paz, Madrid, Spain. - Author
General Pediatrics, Hospital Puerta de Hierro, Madrid, Spain. - Author
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain. - Author
Infectious Diseases Department, General Pediatrics, Hospital Gregorio Marañón, Madrid, Spain. - Author
Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain. - Author
Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain. - Author
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Abstract

We analyzed 136 children with tuberculosis disease or infection and a positive QuantiFERON-TB (QFT) assay, followed-up for a median of 21 months (0.4-11years). QFT reversed in 16.9% of cases, with significant decreases in TB1 (-1.72 vs. -0.03 IU/ml, p=0.001) and TB2 (-1.65 vs. -0.43 IU/ml, p=0.005) levels compared to non-reverters. We found a higher QFT reversion rate among children under 5 years (25.0% vs 11.9%, p=0.042), and those with TST induration <15mm (29% vs 13.3%, p=0.055). Our data reveal that, although QFT test remained positive in the majority of children, reversion occurred in 16% of cases in a progressive and stable pattern. Younger age and reduced TST induration were associated with QFT reversion.

Keywords
AdolescentAdolescentsChildChild, preschoolChildrenHumansQuantiferon-tbReversion rateTuberculin testTuberculosis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers in Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 38/181, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-10:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 3.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.75.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rodríguez-Molino P) and Last Author (SAINZ COSTA, TALIA).