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Analysis of institutional authors

Ortiz, AlbertoAuthorSanchez-Niño, María DoloresCorresponding Author

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December 25, 2023
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SCARF Genes in COVID-19 and Kidney Disease: A Path to Comorbidity-Specific Therapies

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24 (22): 16078- - 2023-11-01 24(22), DOI: 10.3390/ijms242216078

Authors: Carriazo, Sol; Abasheva, Daria; Duarte, Deborah; Ortiz, Alberto; Sanchez-Nino, Maria Dolores

Affiliations

IIS Fdn Jimenez Diaz UAM, Dept Nephrol & Hypertens, Madrid 28049, Spain - Author
RICORS2040, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Fac Med, Dept Med, Madrid 28049, Spain - Author
Univ Toronto, Dept Med, Div Nephrol, Univ Hlth Network, Toronto, ON M5G 2C4, Canada - Author
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Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has killed similar to 7 million persons worldwide. Chronic kidney disease (CKD) is the most common risk factor for severe COVID-19 and one that most increases the risk of COVID-19-related death. Moreover, CKD increases the risk of acute kidney injury (AKI), and COVID-19 patients with AKI are at an increased risk of death. However, the molecular basis underlying this risk has not been well characterized. CKD patients are at increased risk of death from multiple infections, to which immune deficiency in non-specific host defenses may contribute. However, COVID-19-associated AKI has specific molecular features and CKD modulates the local (kidney) and systemic (lung, aorta) expression of host genes encoding coronavirus-associated receptors and factors (SCARFs), which SARS-CoV-2 hijacks to enter cells and replicate. We review the interaction between kidney disease and COVID-19, including the over 200 host genes that may influence the severity of COVID-19, and provide evidence suggesting that kidney disease may modulate the expression of SCARF genes and other key host genes involved in an effective adaptive defense against coronaviruses. Given the poor response of certain CKD populations (e.g., kidney transplant recipients) to SARS-CoV-2 vaccines and their suboptimal outcomes when infected, we propose a research agenda focusing on CKD to develop the concept of comorbidity-specific targeted therapeutic approaches to SARS-CoV-2 infection or to future coronavirus infections.

Keywords

Acute kidney injuryAcute respiratory syndromeCell entryChronic kidney diseaseComorbidityCovid-19Covid-19 vaccinesFunctional receptorGenetic predispositionHumansInjuryMortalityProteinRenal insufficiency, chronicReplicationSarsSars-cov-2ScarfSpike glycoproteinSyndrome coronavirusVirus

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 66/313, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-08:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Canada.

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (SANCHEZ NIÑO, MARIA DOLORES).

    the author responsible for correspondence tasks has been SANCHEZ NIÑO, MARIA DOLORES.