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Analysis of institutional authors

Herrero-Fernandez BAuthorGomez-Bris RAuthorGonzález-Granado JmCorresponding Author

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February 6, 2023
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Pathophysiology of Inflammatory Bowel Disease: Innate Immune System

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24 (2): 1526- - 2023-01-01 24(2), DOI: 10.3390/ijms24021526

Authors: Saez, Angela; Herrero-Fernandez, Beatriz; Gomez-Bris, Raquel; Sanchez-Martinez, Hector; Gonzalez-Granado, Jose M M

Affiliations

CIBER Enfermedades Cardiovasc CIBERCV, Madrid 28029, Spain - Author
Ctr Nacl Invest Cardiovasc CNIC, Madrid 28029, Spain - Author
Inst Invest Sanitaria Hosp 12 Octubre imas12, LamImSys Lab, Madrid 28041, Spain - Author
Univ Autonoma Madrid UAM, Fac Med, Dept Fisiol, Madrid 28029, Spain - Author
Univ Complutense Madrid UCM, Sch Med, Dept Immunol Ophthalmol & ENT, Madrid 28040, Spain - Author
Univ Francisco Vitoria UFV, Fac Ciencias Expt, Pozuelo De Alarcon 28223, Spain - Author
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Abstract

Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause. Intestinal innate immunity is enacted by neutrophils, monocytes, macrophages, and dendritic cells (DCs), and innate lymphoid cells and NK cells, characterized by their capacity to produce a rapid and nonspecific reaction as a first-line response. Innate immune cells (IIC) defend against pathogens and excessive entry of intestinal microorganisms, while preserving immune tolerance to resident intestinal microbiota. Changes to this equilibrium are linked to intestinal inflammation in the gut and IBD. IICs mediate host defense responses, inflammation, and tissue healing by producing cytokines and chemokines, activating the complement cascade and phagocytosis, or presenting antigens to activate the adaptive immune response. IICs exert important functions that promote or ameliorate the cellular and molecular mechanisms that underlie and sustain IBD. A comprehensive understanding of the mechanisms underlying these clinical manifestations will be important for developing therapies targeting the innate immune system in IBD patients. This review examines the complex roles of and interactions among IICs, and their interactions with other immune and non-immune cells in homeostasis and pathological conditions.

Keywords

apoptotic neutrophilscd103(+) dendritic cellscolony-stimulating factor-1crohn's diseasecrohn’s diseasedendritic cellgm-csfinflammatory bowel diseaseinnate immune systemintestinal homeostasisintestinal macrophageslymphoid-cellsmacrophagemononuclear phagocyte systemneutrophiltissue-residentulcerative colitisulcerative-colitisCrohn’s diseaseDendritic cellHumansImmune systemImmunity, innateInflammationInflammatory bowel diseaseInflammatory bowel diseasesInnate immune systemIntestinal homeostasisIntestinal mucosaLymphocytesMacrophageNeutrophilNeutrophil extracellular trapsUlcerative colitis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 66/313, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 93.66, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 111
  • Scopus: 196
  • Europe PMC: 61

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 511.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 561 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.5.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/718829

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (GONZALEZ GRANADO, JOSE MARIA).

the author responsible for correspondence tasks has been GONZALEZ GRANADO, JOSE MARIA.