{rfName}
Ca

Indexed in

License and use

Icono OpenAccess

Citations

21

Altmetrics

Grant support

LB and AL-B are supported by the Irish Research Council (IRCL/2017/78). RA is supported by Ministerio de Ciencia, Innovacion y Universidades (PID2019-111510RB-I00) and Universidad Rey Juan Carlos.

Analysis of institutional authors

Llorente-Berzal, AlvaroCorresponding Author

Share

December 21, 2022
Publications
>
Review
Sí

Cannabinoid Drugs-Related Neuroprotection as a Potential Therapeutic Tool Against Chemotherapy-Induced Cognitive Impairment

Publicated to:Frontiers in Pharmacology. 12 734613- - 2021-11-12 12(), DOI: 10.3389/fphar.2021.734613

Authors: Boullon, Laura; Abalo, Raquel; Llorente-Berzal, Alvaro;

Affiliations

CSIC, Unidad Asociada IDi Inst Quim Medica IQM, Madrid, Spain - Author
High Performance Res Grp Physiopathol & Pharmaco, Madrid, Spain - Author
Natl Univ Ireland, Ctr Pain Res, Galway, Ireland - Author
Natl Univ Ireland, Galway Neurosci Ctr, Galway, Ireland - Author
Natl Univ Ireland, Sch Med, Pharmacol & Therapeut, Galway, Ireland - Author
Univ Rey Juan Carlos URJC, Dept Ciencias Basicas Salud, Area Farmacol Nutr, Alcorcon, Spain - Author
Working Grp Basic Sci Pain & Analgesia Spanish P, Grupo Trabajo Ciencias Basicas Dolor Analgesia So, Madrid, Spain - Author
See more

Abstract

In recent years, and particularly associated with the increase of cancer patients' life expectancy, the occurrence of cancer treatment sequelae, including cognitive impairments, has received considerable attention. Chemotherapy-induced cognitive impairments (CICI) can be observed not only during pharmacological treatment of the disease but also long after cessation of this therapy. The lack of effective tools for its diagnosis together with the limited treatments currently available for alleviation of the side-effects induced by chemotherapeutic agents, demonstrates the need of a better understanding of the mechanisms underlying the pathology. This review focuses on the comprehensive appraisal of two main processes associated with the development of CICI: neuroinflammation and oxidative stress, and proposes the endogenous cannabinoid system (ECS) as a new therapeutic target against CICI. The neuroprotective role of the ECS, well described in other cognitive-related neuropathologies, seems to be able to reduce the activation of pro-inflammatory cytokines involved in the neuroinflammatory supraspinal processes underlying CICI. This review also provides evidence supporting the role of cannabinoid-based drugs in the modulation of oxidative stress processes that underpin cognitive impairments, and warrant the investigation of endocannabinoid components, still unknown, that may mediate the molecular mechanism behind this neuroprotective activity. Finally, this review points forward the urgent need of research focused on the understanding of CICI and the investigation of new therapeutic targets.

Keywords

cannabinoid drugschemotherapy-induced cognitive impairmentendocannabinoid systemneuroinflammationAcid amide hydrolaseAlzheimers-diseaseCannabinoid drugsCb2 receptorChemotherapy-induced cognitive impairmentEndocannabinoid systemIn-vivoInduced apoptosisInduced nephrotoxicityInduced neurotoxicityNeuroinflammationOxidative stressParkinsons-disease

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers in Pharmacology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 50/279, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.74, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 6
  • Europe PMC: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 36.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 40 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.7.
  • The number of mentions on the social network X (formerly Twitter): 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (LLORENTE BERZAL, ALVARO).

the author responsible for correspondence tasks has been LLORENTE BERZAL, ALVARO.