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Grant support

We are grateful for the financial support provided by the Fondo Social Europeo-Gobierno de Aragon, Ministerio de la Economia y Competitividad del Gobierno de Espana for the public funding of Proyectos I+D+I - Programa Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad (project no. SAF2014-54763-C2-2-R), Ministerio de Educacion, Cultura y Deportes (A. A., FPU grant (FPU014/06249)), Ministerio de Economia y Competitividad (I. S. S., FPI grant, BES-2015-071304) and the Fundacion General CSIC (S. G. M., Programa ComFuturo). Authors gratefully acknowledge Servier Medical Art PowerPoint image bank for most of the elements employed in the figures.

Analysis of institutional authors

Artiga, AlvaroAuthor

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December 21, 2022
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Review
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Current status and future perspectives of gold nanoparticle vectors for siRNA delivery

Publicated to:Journal of Materials Chemistry B. 7 (6): 876-896 - 2019-01-01 7(6), DOI: 10.1039/c8tb02484g

Authors: Artiga, Alvaro; Serrano-Sevilla, Ines; De Matteis, Laura; Mitchell, Scott G.; de la Fuente, Jesus M.;

Affiliations

CIBER BBN, C Mariano Esquillor S-N, Zaragoza 50018, Spain - Author
CIBER BBN, C Pedro Cerbuna 12, Zaragoza 50009, Spain - Author
Univ Zaragoza, CSIC, ICMA, C Pedro Cerbuna 12, E-50009 Zaragoza, Spain - Author
Univ Zaragoza, INA, C Mariano Esquillor S-N, Zaragoza 50018, Spain - Author

Abstract

Discovering the vast therapeutic potential of siRNA opened up new clinical research areas focussing on a number of diseases and applications; however significant problems with siRNA stability and delivery have hindered its clinical applicability. As a result, interest in the development of practical siRNA delivery systems has grown in recent years. Of the numerous siRNA delivery strategies currently on offer, gold nanoparticles (AuNPs) stand out thanks to their biocompatibility and capacity to protect siRNA against degradation; not to mention the versatility offered by their tuneable shape, size and optical properties. Herein this review provides a complete summary of the methodologies for functionalizing AuNPs with siRNA, paying singular attention to the AuNP shape, size and surface coating, since these key factors heavily influence cellular interaction, internalization and, ultimately, the efficacy of the hybrid particle. The most noteworthy hybridization strategies have been highlighted along with the most innovative and outstanding in vivo studies with a view to increasing clinical interest in the use of AuNPs as siRNA nanocarriers.

Keywords

Breast-cancerCo-deliveryDrug-deliveryIn-vitroOf-the-artPhotothermal therapyProstate-cancerProtein coronaSmall interfering rnaSystemic delivery

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal of Materials Chemistry B due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 9/38, thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Science, Biomaterials.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.17. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.7 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 7.76 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-19, the following number of citations:

  • WoS: 51
  • Scopus: 53

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 90.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 93 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.35.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).
  • The number of mentions on Wikipedia: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (ARTIGA FOLCH, ALVARO) .