{rfName}
Cl

Indexed in

License and use

Citations

196

Altmetrics

Analysis of institutional authors

Provencio Pulla, MarianoAuthorMorado, MartaAuthor

Share

April 6, 2015
Publications
>
Article
No

Clinical significance of occult cerebrospinal fluid involvement assessed by flow cytometry in non-Hodgkin's lymphoma patients at high risk of central nervous system disease in the rituximab era

Publicated to:EUROPEAN JOURNAL OF HAEMATOLOGY. 85 (4): 321-328 - 2010-10-01 85(4), DOI: 10.1111/j.1600-0609.2010.01478.x

Authors: Sancho, Juan-Manuel; Orfao, Alberto; Quijano, Sandra; Garcia, Olga; Panizo, Carlos; Perez-Ceballos, Elena; Deben, Guillermo; Salar, Antonio; Gonzalez-Barca, Eva; Alonso, Natalia; Garcia-Vela, Jose-Antonio; Capote, Javier; Penalver, Francisco-Javier; Provencio, Mariano; Arias, Jesus; Plaza, Josefa; Caballero, Dolores; Morado, Marta; Feliu, Evarist; Ribera, Josep-Maria

Affiliations

CHUS, Serv Hematol, Santiago De Compostela, Spain - Author
Fdn Hosp Alcorcon, Serv Hematol, Madrid, Spain - Author
Hosp Clin Univ Salamanca, Serv Hematol, Salamanca, Spain - Author
Hosp del Mar, Serv Hematol, Barcelona, Spain - Author
Hosp Juan Canalejo, Serv Hematol, La Coruna, Spain - Author
Hosp La Paz, Serv Hematol, Madrid, Spain - Author
Hosp Morales Meseguer, Serv Hematol, Murcia, Spain - Author
Hosp Puerta de Hierro, Serv Oncol, Madrid, Spain - Author
Hosp Puerta del Mar, Serv Hematol, Cadiz, Spain - Author
Hosp Univ Getafe, Serv Hematol, Madrid, Spain - Author
Hosp Xeral Calde, Serv Hematol, Lugo, Spain - Author
Hosp Xeral Cies, Serv Hematol, Vigo, Spain - Author
ICO Hosp Duran & Reynals, Serv Hematol, Barcelona, Spain - Author
Univ Autonoma Barcelona, Dept Clin Hematol, ICO Hosp Germans Trias & Pujol, Barcelona 08916, Spain - Author
Univ Navarra Clin, Serv Hematol, Pamplona, Spain - Author
Univ Salamanca, CIC, USAL CSIC, E-37008 Salamanca, Spain - Author
Univ Salamanca, Dept Med, Serv Gen Citometria, E-37008 Salamanca, Spain - Author
See more

Abstract

Flow cytometry (FCM) analysis of cerebrospinal fluid (CSF) is more sensitive than conventional cytology (CC) for diagnosis of lymphomatous meningeosis, but the clinical significance of occult central nervous system (CNS) disease (positive FCM with negative CC) remains unknown.CSF samples from 105 patients with newly diagnosed aggressive lymphomas at high risk of CNS involvement were prospectively studied by both CC and FCM, and results were correlated with cumulative incidence of CNS relapse and overall survival (OS). Patients were divided into three groups: 1) patients without CNS involvement (CC-/FCM-; n=83); 2) individuals with occult CNS disease (FCM+/CC-; n=15); and 3) cases with CNS disease (CC+/FCM+; n=7).Six cases showed CNS relapse or progression: two in Group 1 (2.4%), two in Group 2 (13%) and two in Group 3 (28.5%) (Group 2 vs. 1, P=0.04; Group 3 vs. 1, P<0.001). Patients from Groups 2 (P=0.05) and 3 (P<0.001) also showed a higher cumulative incidence of CNS relapse than those from Group 1. Significant differences were observed in OS between FCM-/CC- and FCM+/CC+ cases (P=0.02), while patients with occult CNS disease (FCM+/CC-) displayed intermediate OS rates, although differences did not reach statistical significance.The presence of occult CNS involvement at diagnosis in patients with NHL at high risk of CNS disease is associated with a higher probability of CNS relapse.© 2010 John Wiley & Sons A/S.

Keywords

Central nervous systemCerebrospinal fluidFlow cytometryIntrathecalNon-hodgkin's lymphomaRelapse

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EUROPEAN JOURNAL OF HAEMATOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 8.92, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Sep 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-09-04, the following number of citations:

  • WoS: 43
  • Scopus: 51
  • Europe PMC: 31
  • Google Scholar: 70

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-09-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 35.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 35 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: MALDEN.