Introduction: There is a gap in the literature in relation to the holistic approach of the integration process of patients and relatives to Parkinson's disease (PD). Aim: To explore the process of adaptation and living with PD experienced by patients and relatives, and the factors and mechanisms that ease or hinder this. Methods: The ReNACE Project is a mixed method, multicentred and multidisciplinary Project (3 years) with two phases (qualitative and quantitative). It is being developed in the Clínica Universidad de Navarra, a health centre of the SNS-Osasunbidea, and the Navarre Parkinson Association. Preliminary results from phase I Qualitative are presented. Data were collected through semi-structured interviews, socio-demographic forms and scales (Parkinson staging). Comparative content (NVivo programme) and statistical analyses (SPSS 15.0) were performed. Results: Fifteen patients with PD and 16 relatives participated in the study. Their median and interquartile range age was 73 (65-76.25) and 65 (59.5-74) years, respectively. Two main dynamic stages emerged regarding the adaptation process to PD: 1. Extraordinary Stage, 2. Normalisation Stage. The main factors and mechanisms that influenced the process of living with PD were: coping strategies, family support, personal and social networks, resources, and education and information. Conclusions: Living with Parkinson's disease is a dynamic and complex process influenced by factors related to the disease and personality, which require a holistic approach. © 2012 Sociedad spañola de Enfermería Neurológica. Publicado por Elsevier España, S.L. Todos los derechos reservados.