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Analysis of institutional authors

Negredo Madrigal, PilarAuthorBuendia Abaitua, IzaskunAuthorGarcia Lopez, ManuelaAuthorParada, EstherAuthorEgea, JavierAuthor

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January 29, 2014
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The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2

Publicated to:ANTIOXIDANTS & REDOX SIGNALING. 19 (11): 1135-1148 - 2013-10-10 19(11), DOI: 10.1089/ars.2012.4671

Authors: Parada, Esther; Egea, Javier; Buendia, Izaskun; Negredo, Pilar; Cunha, Ana C; Cardoso, Silvia; Soares, Miguel P; Lopez, Manuela G

Affiliations

Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal - Author
UAM-Instituto Teofilo Hernando de I+D del Medicamento - Author
Univ Autonoma Madrid, Hosp Univ La Princesa IP, Inst Invest Sanitaria, E-28029 Madrid, Spain - Author
Univ Autonoma Madrid, Inst Teofilo Hernando, E-28029 Madrid, Spain - Author
Univ Autonoma Madrid, Inst Univ Paz IdiPaz, E-28029 Madrid, Spain - Author
Univ Autonoma Madrid, Sch Med, Dept Anat Histol & Neurosci, E-28029 Madrid, Spain - Author
Univ Autonoma Madrid, Sch Med, Dept Pharmacol, E-28029 Madrid, Spain - Author
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Abstract

We asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or the expression of its target cytoprotective gene, heme oxygenase-1 (HO-1). Specifically, the protective effect of the pharmacologic alpha-7 nicotinic acetylcholine receptor (?7 nAChR) agonist PNU282987 was analyzed in organotypic hippocampal cultures (OHCs) subjected to oxygen and glucose deprivation (OGD) in vitro as well as in photothrombotic stroke in vivo.OHCs exposed to OGD followed by reoxygenation elicited cell death, measured by propidium iodide and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide staining. Activation of ?7 nAChR by PNU282987, after OGD, reduced cell death, reactive oxygen species production, and tumor necrosis factor release. This was associated with induction of HO-1 expression, an effect reversed by ?-bungarotoxin and by tin-protoporphyrin IX. The protective effect of PNU282987 was lost in microglial-depleted OHCs as well as in OHCs from Nrf2-deficient-versus-wild-type mice, an effect associated with suppression of HO-1 expression in microglia. Administration of PNU282987 1?h after induction of photothrombotic stroke in vivo reduced the infarct size and improved motor skills in Hmox1(lox/lox) mice that express normal levels of HO-1, but not in LysM(Cre)Hmox1(?/?) in which HO-1 expression is inhibited in myeloid cells, including the microglia.This study suggests the participation of the microglial ?7 nAChR in the brain cholinergic anti-inflammatory pathway.Activation of the ?7 nAChR/Nrf2/HO-1 axis in microglia regulates neuroinflammation and oxidative stress, affording neuroprotection under brain ischemic conditions.

Keywords

Blood mononuclear-cellsCarbon-monoxideEarly embryonic lethalityHuman mitochondrial thioredoxinInactivationInteracting-protein txnipIschemia-reperfusion injuryLeukemia-derived factorMiceNf-kappa-bOxidative stressP53Promotes oxidative stressRecombinant human thioredoxinTransformationTumor-necrosis-factorUp-regulated protein-1

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ANTIOXIDANTS & REDOX SIGNALING due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position 9/124, thus managing to position itself as a Q1 (Primer Cuartil), in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 5.08. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.85 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 17.7 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-28, the following number of citations:

  • WoS: 152
  • Scopus: 166
  • Europe PMC: 103

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-28:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 117.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 117 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/662894

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Portugal; United States.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PARADA PEREZ, ESTHER) .