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Research was funded through grants BFU2015-66040-P and MDM-2016-0687 (to F.C.) and BFU2014-53299-P (to D.G.M.) from the Ministerio de Ciencia, Innovacion y Universidades (Spain).

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Miguez, David G.Author

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June 3, 2019
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Dynamic Hh signalling can generate temporal information during tissue patterning

Publicated to:DEVELOPMENT. 146 (8): dev176933- - 2019-04-15 146(8), DOI: 10.1242/dev.176933

Authors: Garcia-Morales, Diana; Navarro, Tomas; Iannini, Antonella; Pereira, Paulo S.; Miguez, David G.; Casares, Fernando;

Affiliations

;Univ Pablo de Olavide Junta Andalucia, CSIC, CABD, CEM Unit DMC2, Campus UPO, Seville 41013, Spain      Consejo Superior de Investigaciones Cientificas (CSIC)    Universidad Pablo de Olavide    Andalusian Center for Developmental Biology (CABD);Univ Porto, Inst Biol Mol & Celular i3S, P-4200135 Porto, Portugal      Universidade do Porto;UAM, CSIC, Ctr Biol Mol Severo Ochoa, Campus Cantoblanco, Madrid 28049, Spain      CSIC - Centro de Biologia Molecular Severo Ochoa (CBM)    Consejo Superior de Investigaciones Cientificas (CSIC)    Autonomous University of Madrid - Author
UAM, CSIC, Ctr Biol Mol Severo Ochoa, Campus Cantoblanco, Madrid 28049, Spain.      Autonomous University of Madrid    CSIC - Centro de Biologia Molecular Severo Ochoa (CBM)    Consejo Superior de Investigaciones Cientificas (CSIC) - Author
Univ Pablo de Olavide Junta Andalucia, CSIC, CABD, CEM Unit DMC2, Campus UPO, Seville 41013, Spain.      Andalusian Center for Developmental Biology (CABD)    Universidad Pablo de Olavide    Consejo Superior de Investigaciones Cientificas (CSIC) - Author

Abstract

The differentiation of tissues and organs requires that cells exchange information in space and time. Spatial information is often conveyed by morphogens: molecules that disperse across receiving cells to generate signalling gradients. Cells translate such concentration gradients into space-dependent patterns of gene expression and cellular behaviour. But could morphogen gradients also convey developmental time? Here, by investigating the developmental role of Hh on a component of the Drosophila visual system, the ocellar retina, we have discovered that ocellar cells use the non-linear gradient of Hh as a temporal cue, collectively performing the biological equivalent of a mathematical logarithmic transformation. In this way, a morphogen diffusing from a non-moving source is decoded as a wave of differentiating photoreceptors that travels at constant speed throughout the retinal epithelium.

Keywords

drosophilahedgehogpatterningsystems modellingCubitus-interruptus proteinDrosophilaDrosophila segmentExpressionEyeHedgehogHedgehog morphogen gradientOrthodenticlePatterningSonic hedgehogSpecificationSystems modellingTranscription factorVisual systemWingless

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal DEVELOPMENT due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 5/41, thus managing to position itself as a Q1 (Primer Cuartil), in the category Developmental Biology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.12, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 5
  • Scopus: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 22.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 15.3.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 26 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.