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Nationwide COVID-19-EII Study: Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry

Publicado en:Journal of Clinical Medicine. 11 (2): 421- - 2022-01-01 11(2), DOI: 10.3390/jcm11020421

Autores: Zabana, Yamile; Marin-Jimenez, Ignacio; Rodriguez-Lago, Iago; Vera, Isabel; Martin-Arranz, Maria Dolores; Guerra, Ivan; Gisbert, Javier P; Mesonero, Francisco; Benitez, Olga; Taxonera, Carlos; Ponferrada-Diaz, Angel; Piqueras, Marta; Lucendo, Alfredo J; Caballol, Berta; Manosa, Miriam; Martinez-Montiel, Pilar; Bosca-Watts, Maia; Gordillo, Jordi; Bujanda, Luis; Mancenido, Noemi; Martinez-Perez, Teresa; Lopez, Alicia; Rodriguez-Gutierrez, Cristina; Garcia-Lopez, Santiago; Vega, Pablo; Rivero, Montserrat; Melcarne, Luigi; Calvo, Maria; Iborra, Marisa; Barreiro de-Acosta, Manuel; Sicilia, Beatriz; Barrio, Jesus; Perez, Jose Lazaro; Busquets, David; Perez-Martinez, Isabel; Navarro-Llavat, Merce; Hernandez, Vicent; Argueelles-Arias, Federico; Ramirez Esteso, Fernando; Meijide, Susana; Ramos, Laura; Gomollon, Fernando; Munoz, Fernando; Suris, Gerard; de Zarate, Jone Ortiz; Huguet, Jose Maria; Llao, Jordina; Garcia-Sepulcre, Mariana Fe; Sierra, Monica; Dura, Miguel; Estrecha, Sandra; Fuentes Coronel, Ana; Hinojosa, Esther; Olivan, Lorenzo; Iglesias, Eva; Gutierrez, Ana; Varela, Pilar; Rull, Nuria; Gilabert, Pau; Hernandez-Camba, Alejandro; Brotons, Alicia; Ginard, Daniel; Sese, Eva; Carpio, Daniel; Aceituno, Montserrat; Cabriada, Jose Luis; Gonzalez-Lama, Yago; Jimenez, Laura; Chaparro, Maria; Lopez-San Roman, Antonio; Alba, Cristina; Plaza-Santos, Rocio; Mena, Raquel; Tamarit-Sebastian, Sonsoles; Ricart, Elena; Calafat, Margalida; Olivares, Sonsoles; Navarro, Pablo; Bertoletti, Federico; Alonso-Galan, Horacio; Pajares, Ramon; Olcina, Pablo; Manzano, Pamela; Domenech, Eugeni; Esteve, Maria

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Resumen

We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March–July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twenty-eight percent were infected in the work environment, and 48% were infected by intrafamilial transmission, despite having good adherence to lockdown. Thirty-five percent required hospitalization, 7.9% had severe COVID-19 and 3.7% died. Similar data were reported in the general population (hospitalisation 19.5%, ICU 2.1% and mortality 4.6%). Factors related to death and severe COVID-19 were being aged ≥ 60 years (OR 7.1, 95% CI: 1.8–27 and 4.5, 95% CI: 1.3–15.9), while having ≥2 comorbidities increased mortality (OR 3.9, 95% CI: 1.3–11.6). None of the drugs for IBD were related to severe COVID-19. Immunosuppression was definitively stopped in 1% of patients at 12 months. The prognosis of COVID-19 in IBD, even in immunosuppressed patients, is similar to that in the general population. Thus, there is no need for more strict protection measures in IBD.

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