Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

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Rodriguez-Artalejo FAuthorLaclaustra, MartinAuthorBanegas JrAuthorTellez-Plaza, MariaAuthorGuallar-Castillon, PilarAuthor

October 8, 2025

Publications

Article

Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

Publicated to: European Journal Of Epidemiology. 40 (5): 581-599 - 2025-05-12 40(5), DOI: 10.1007/s10654-025-01229-6

Authors:

Hernaez, Alvaro; Camps-Vilaro, Anna; Polo-Alonso, Sara; Subirana, Isaac; Ramos, Rafel; de Cid, Rafael; Rodriguez-Artalejo, Fernando; Elosua, Roberto; Chirlaque, M Dolores; Chirlaque, M Dolores; Amiano, Pilar; Bermudez-Lopez, Marcelino; Guevara, Marcela; Cinza-Sanjurjo, Sergio; Sanchez, Maria-Jose; de Leon, Antonio Cabrera; Laclaustra, Martin; Rojo-Martinez, Gemma; Guembe-Suescun, Maria J; Guembe-Suescun, Maria J; Perez-Gomez, Beatriz; Vega-Alonso, Tomas; Toran-Monserrat, Pere; Lora-Pablos, David; Huerta, Jose Maria; Valdivielso, Jose M; Valdivielso, Jose M; Degano, Irene R; Degano, Irene R; Felix-Redondo, Francisco J; Felix-Redondo, Francisco J; Gandarillas, Ana Maria; Valdes, Sergio; Mundet-Tuduri, Xavier; Sanchez, Pedro L; Sanchez, Pedro L; Martin-Sanchez, Vicente; Rigo, Fernando; Alonso-Sampedro, Manuela; Moreno-Iribas, Conchi; Martin-Escudero, Juan Carlos; Delgado, Elias; Grau, Maria; Urrutia, Ines; Ovejero, Diana; Quintela, Ines; Marti-Lluch, Ruth; Blay, Natalia; Banegas, Jose R; Banegas, Jose R; Tizon-Marcos, Helena; Gomez, Jesus Humberto; Aizpurua, Amaia; Castro-Boque, Eva; Delfrade, Josu; Prieto-Diaz, Miguel Angel; Rodriguez-Barranco, Miguel; Almeida-Gonzalez, Delia; Moreno-Franco, Belen; Oualla-Bachiri, Wasima; Sayon-Orea, Carmen; Plans-Beriso, Elena; Lozano, Jose Eugenio; Lopez-Lifante, Victor M; Lopez-Lifante, Victor M; Cancelas-Navia, Pilar; Cabrera-Castro, Natalia; Cambray, Serafi; Zacarias-Pons, Lluis; Fernandez-Berges, Daniel; Donoso-Navarro, Encarnacion; Maldonado-Araque, Cristina; Franch-Nadal, Josep; Dorado-Diaz, Pedro Ignacio; Villarin-Castro, Alejandro; Frontera-Juan, Guillem; Gude, Francisco; Andueza, Naroa; Tellez-Plaza, Maria; Ares-Blanco, Jessica; Cruz, Raquel; Ribas-Aulinas, Marc; Barretina, Jordi; Guallar-Castillon, Pilar; Cainzos-Achirica, Miguel; Colorado-Yohar, Sandra Milena; Llorente, Adrian; Diaz-Tocados, Juan Miguel; Ardanaz, Eva; Mico-Perez, Rafael Manuel; Fernandez-Martinez, Nicolas Francisco; del Cristo Rodriguez-Perez, Maria; Cenarro, Ana; Calle-Pascual, Alfonso L; Calle-Pascual, Alfonso L; Marrugat, Jaume

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Affiliations

12 Octubre imas12, Inst Invest Sanitaria Hosp Univ, Madrid, Spain - Author

Asturias Cent Univ Hosp, Oviedo, Spain - Author

August Pi & Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain - Author

BioGipuzkoa Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain - Author

Complejo Asistencial Univ Salamanca, Salamanca, Spain - Author

Consejeria Sanidad Junta Castilla & Leon, Direcc Gen Salud Publ, Valladolid, Spain - Author

Consejeria Sanidad, Subdirecc Gen Vigilancia Salud Publ, Direcc Gen Salud Publ, Madrid, Spain - Author

Doctor Trueta Univ Hosp, Girona Biomed Res Inst IDIBGI, Girona, Spain - Author

Escuela Andaluza Salud Publ, Granada, Spain - Author

European Reference Network Rare Endocrine Condit E, Leiden, Netherlands - Author

Fdn Publ Galega Med Xen, Ctr Nacl Genotipado CEGEN, Santiago De Compostela, Spain - Author

Fontanars Alforins Hlth Ctr, Xat Ontinyent Dept Hlth, Valencia, Spain - Author

Germans Trias & Pujol Res Inst IGTP, CORE Program, Genomes Life GCAT Lab, Badalona, Spain - Author

Germans Trias & Pujol Res Inst IGTP, Grp Recerca Impacte Malalties Croniquesles & Seves, Badalona, Spain - Author

Germans Trias & Pujol Res Inst, Can Ruti Campus, Badalona, Spain - Author

Govt Navarre, Dept Hlth, Vasc Risk Navarre Invest Grp, Pamplona, Spain - Author

Hlth Area Santiago de Compostela, Milladoiro Hlth Ctr, Santiago De Compostela, Spain - Author

Hlth Res Inst Principal Asturias ISPA, Endocrinol Nutr Diabet & Obes Grp, Oviedo, Spain - Author

Hlth Res Inst Santiago de Compostela IDIS, Res Methods Grp RESMET, Santiago De Compostela, Spain - Author

Hosp Clin Univ San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Endocrinol & Nutr Dept, Madrid, Spain - Author

Hosp Mar Res Inst IMIM, Cardiovasc Epidemiol & Genet Res Grp, Barcelona, Spain - Author

Hosp Mar Res Inst IMIM, Musculo Skeletal Res Unit, Barcelona, Spain - Author

Hosp Mar Res Inst IMIM, REGICOR Study Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain - Author

Hosp Mar, Cardiol Serv, Barcelona, Spain - Author

Hosp Univ Cruces, Inst Invest Sanitaria Biocruces, Baracaldo, Spain - Author

Hosp Univ Miguel Servet, Translat Res Unit, Zaragoza, Spain - Author

Hosp Univ Navarra, Serv Apoyo Gest Clin & Continuidad Asistencial, Pamplona, Spain - Author

Hosp Univ Son Espases Atenc Primaria Mallorca, Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca, Spain - Author

IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain - Author

Inst Aragones Ciencias Salud IACS, Zaragoza, Spain - Author

Inst Catala Salut, Primary Healthcare Ctr Palau Solita & Plegamans, Gerencia Atencio Primaria Metropolitana Nord, Barcelona, Spain - Author

Inst Invest Biomed Malaga IBIMA Plataforma Bionand, Malaga, Spain - Author

Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain - Author

Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain - Author

Inst Recerca Biomed Lleida IRBLleida, Vasc & Renal Translat Res Grp, Lleida, Spain - Author

Inst Res & Innovat Life Sci & Hlth Cent Catalonia, Vic, Spain - Author

Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBERD, Madrid, Spain - Author

Inst Salud Carlos III, CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain - Author

Inst Salud Carlos III, CIBER Enfermedades Raras CIBERER, Madrid, Spain - Author

Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain - Author

Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain - Author

Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBERF, Madrid, Spain - Author

Inst Salud Carlos III, Natl Ctr Epidemiol, Dept Chron Dis, Madrid, Spain - Author

Inst Salud Carlos III, Network Res Chron Primary Care & Hlth Promot RICAP, Madrid, Spain - Author

Inst Salud Publ & Laboral Navarra, Pamplona, Spain - Author

Inst Univ Recerca Atencio Primaria Salut Jordi Gol, Multidisciplinary Res Grp Hlth & Soc GREMAS, Barcelona, Spain - Author

Inst Univ Recerca Atencio Primaria Salut Jordi Gol, Unitat Suport Recerca Barcelona, Barcelona, Spain - Author

Inst Univ Recerca Atencio Primaria Salut Jordi Gol, Unitat Suport Recerca Metropolitana Nord, Mataro, Spain - Author

Inst Univ Recerca Atencio Primaria Salut Jordi Gol, Vasc Hlth Res Grp, Girona, Spain - Author

Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain - Author

Navarra Inst Hlth Res IdiSNA, Pamplona, Spain - Author

PhD Program, Barcelona, Spain - Author

Principal Asturias Hlth Serv, Vallobin Florida Hlth Ctr, Oviedo, Spain - Author

Puerta Hierro Majadahonda Univ Hosp, Dept Biochem Clin Anal, Madrid, Spain - Author

Serv Extremeno Salud Villanueva Serena, Res Unit Don Benito Villanueva Serena Hlth Area, Badajoz, Spain - Author

Serv Extremeno Salud, Direcc Gen Asistencia Sanitaria, Vic, Spain - Author

Serv Salud Castilla La Mancha, Unidad Docente Multiprofes Atenc Familiar & Comuni, Gerencia Atenc Primaria Toledo, Toledo, Spain - Author

Spanish Clin Res Network SCReN, Madrid, Spain - Author

UAM, IMDEA, Food Inst, CEI,CSIC, Madrid, Spain - Author

Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia - Author

Univ Autonoma Madrid, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain - Author

Univ Barcelona, Dept Med, Sch Med & Hlth Sci, Barcelona, Spain - Author

Univ Complutense Madrid, Fac Estudios Estadisticos, Madrid, Spain - Author

Univ Complutense Madrid, Fac Med, Med Dept 2, Madrid, Spain - Author

Univ Girona UdG, Dept Med Sci, Fac Med, Girona, Spain - Author

Univ Hosp Nuestra Senora Candelaria, Santa Cruz De Tenerife, Spain - Author

Univ Hosp Santiago de Compostela, Dept Med, Santiago De Compostela, Spain - Author

Univ Inst Biosanitary Res Extremadura INUBE, Badajoz, Spain - Author

Univ Laguna, Fac Med, Dept Prevent Med, San Cristobal De La Lagun, Spain - Author

Univ Leon, Inst Biomed IBIOMED, Leon, Spain - Author

Univ Lleida, Dept Basic Med Sci, Lleida, Spain - Author

Univ Lleida, Dept Expt Med, Lleida, Spain - Author

Univ Lleida, Dept Med & Surg, Lleida, Spain - Author

Univ Malaga, Hosp Reg Univ Malaga, Dept Endocrinol & Nutr, Malaga, Spain - Author

Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain - Author

Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain - Author

Univ Oviedo, Dept Med, Oviedo, Spain - Author

Univ Pais Vasco Euskal Herriko Unibertsitatea UPV, Leioa, Spain - Author

Univ Ramon Llull, Blanquerna Sch Hlth Sci, Barcelona, Spain - Author

Univ Salamanca, Inst Invest Biomed Salamanca IBSAL, Salamanca, Spain - Author

Univ Santiago De Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron CI, Santiago De Compostela, Spain - Author

Univ Santiago de Compostela, Fac Med, Santiago De Compostela, Spain - Author

Univ Valladolid, Hosp Univ Rio Hortega, Dept Internal Med, Valladolid, Spain - Author

Univ Vic, Cent Univ Catalonia, Sch Med, Vic, Spain - Author

Univ Zaragoza, Fac Med, Zaragoza, Spain - Author

Abstract

The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population, improve predictions of cardiovascular incidence using genomic and clinical data, and identify subgroups that would benefit most from targeted pharmacological and lifestyle interventions. CORDELIA includes 196,632 individuals (ages 18-84, 54% female, 96% born in Spain, 20% with higher education, recruited from 1989 to 2020, with follow-up periods ranging from 5 to 30 years), with DNA samples available for 117,342 participants (60%). Of the participants, 24% were current smokers, 43% hypertensive, 11% diabetic, 15% medicated with lipid-lowering drugs, 44% overweight, and 27% obese. If not already available, genotyping is being performed using the Axiom (TM) Spain Biobank array (similar to 750,000 variants, including 115,000 specific and 50,000 rare functional variants from the Spanish population). The cohort also includes incident events (coronary heart disease, stroke, heart failure, peripheral artery disease, hypertension, diabetes); date and cause of death; and harmonized data on risk factors (body mass index, waist circumference, lipid profile, blood pressure, glucose, creatinine), lifestyle (smoking, physical activity, diet, alcohol), and socioeconomic status. 99,019 participants (50%) also provide plasma samples. CORDELIA will significantly contribute to understanding the complex interplay of risk factors contributing to cardiovascular disease and advance the fields of precision medicine and public health in Southern European individuals.

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Keywords

Cardiovascular diseaseCardiovascular risk-factorsCohortDiabetes-mellitusGenome-wide association studyMediterranean dietMortalityMyocardial-infarctionPhysical-activityPopulationPrevalencePrimary-careSouthern europeSpainValidity

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EUROPEAN JOURNAL OF EPIDEMIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 25/421, thus managing to position itself as a Q1 (Primer Cuartil), in the category Public, Environmental & Occupational Health. Notably, the journal is positioned above the 90th percentile.

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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Colombia; Netherlands.

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Awards linked to the item

The CORDELIA Study variable harmonization and GWAS were funded by Instituto de Salud Carlos III and co-funded by the European Union (Proyecto de Investigacion de Medicina Personalizada de Precision PMP22/00033, and projects PI21/00040 and PI21/00163). A detailed description of the funding sources of the individual cohorts is available in Appendix II.

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Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

Affiliations

Abstract

Keywords

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Impact and social visibility

Leadership analysis of institutional authors

Awards linked to the item